Retracted and redone Med diet study shows same result: Good
It’s unlikely to surprise people in Greece and on the island of Crete where they’ve been eating fruits, vegetables, nuts and olive oil since ancient times, but a study redone after its methods were found to be flawed has come to the same conclusion: the Mediterranean Diet works.
It took the authors to swallow their pride and acknowledge errors in how the study published in the New England Journal of Medicine in 2013 was done but one of the lead researchers, Dr. Miguel A. Martínez-González of the University of Navarra in Spain, said the result was gratifying.
“After all this long work, I am more convinced than ever” by the study’s data that was redone after some embarrassing moments when the original work was questioned. “Seldom has a trial undergone more scrutiny,” he added.
The results of the retracted, redone study were reported in the New York Times and showed that despite some skepticism that the Mediterranean Diet can cut risk of heart attacks and strokes by 30 percent in those at high risk.
While the research was done in Spain, the diet studied was strikingly similar to that in Greece and other Mediterranean countries and the re-analysis showed essentially what the landmark original did.
Not everyone is convinced. “Nothing they have done in this re-analyzed paper makes me more confident,” said Dr. Barnett Kramer, Director of the Division of Cancer Prevention at the National Cancer Institute told the paper.
The credibility of the study
The flaws threatened to undercut the credibility of the study, especially among doubters and because the assignment of diets into three groups wasn’t as random as it was supposed to be, skewing the first results.
The trial enrolled 7,447 participants aged 55 to 80 who were assigned one of three diets: a Mediterranean diet with at least four tablespoons a day of extra virgin olive oil; the same diet with an ounce of mixed nuts; or a traditional low-fat diet.
The participants were followed for a median of nearly five years. Dr. Martínez-González and his colleagues reported that there were fewer cardiovascular events in the groups consuming olive oil and nuts.
All that came into question last year when Dr. John Carlisle of Torbay Hospital in England challenged the data and a statistician at the New England Journal of Medicine suggested the researchers look at the methods at each center that recruited participants and the not-so-random assignments in some cases.
On re-evaluating their data, the scientists running the new study soon found what Dr. Martínez-González said were “small problems affecting 10 percent of participants.”
Some investigators would assign one person in a household — the wife, for example — to one arm of the study — say, to the group consuming olive oil. Then they would ask other members of the household to share that diet, including them as though they had been randomly assigned to it.
We realized we had never reported that,” Dr. Martínez-González said.It got worse.
Trial in small villages
A researcher at one of the 11 clinical centers in the trial worked in small villages. Participants there complained that some neighbors were receiving free olive oil, while they got only nuts or inexpensive gifts.
So the investigator decided to give everyone in each village the same diet. He never told the leaders of the study what he had done. “He did not think it was important,” Dr. Martínez-González said.
It was because it meant the participants were not randomized and forced the team make another adjustment to data on 652 people in the trial along with 390 others who hadn’t been randomly assigned one of the three diets.
The investigators spent a year working on the re-analysis in collaboration with Dr. Miguel Hernan of the Harvard T.H. Chan School of Public Health.
In the end, they concluded that the original findings were still accurate, but the disbelievers remain unconvinced and excoriated the researchers and the work that created a flawed study in the first place.
“These people were naïve,” said Donald Berry, a statistician at MD Anderson Cancer Center in Houston. “They were sloppy and didn’t know they were being sloppy.”
Cooking with extra virgin olive oil
He said he wants to believe because he loves nuts and has taken to cooking with extra virgin olive oil but doesn’t think the re-analysis solved the study’s problems beyond a doubt that can’t be calculated.
But he remains unconvinced, because the re-analysis did not solve the study’s problems, he said.
Dr. Bradley Efron, a statistics professor at Stanford University, also was skeptical. The revamped results “wouldn’t convince me to be on a Mediterranean diet,” he said.
Dr. Steven Nissen, a cardiologist at the Cleveland Clinic, is persuaded though and said he plans to continue advising patients to go on the Mediterranean Diet and is satisfied with the new findings that were the old findings.
It turned out about 14 percent of the more than 7,400 study participants hadn’t been assigned randomly to either the Mediterranean Diet or a low-fat one.
“This affected only a small part of the trial,” said Martínez González. When the researchers reanalyzed the data excluding the nonrandomized people, the results were the same, he added
Still, because everybody wasn’t randomly assigned to different groups, the study can no longer claim the diet directly caused those health benefits. “We need to tone down the results, but it is just a little bit,” he said, according to NPR.
David Allison, Dean of the School of Public Health at Indiana University in Bloomington told the radio station some logic is needed too, the way he put it.
“I don’t know anybody who would turn around from this and say, ‘Now that this has been revealed, we should all eat cotton candy and turn away from the Mediterranean Diet'”
Read more at thenationalherald.com
RELATED TOPICS: Greece, Greek tourism news, Tourism in Greece, Greek islands, Hotels in Greece, Travel to Greece, Greek destinations , Greek travel market, Greek tourism statistics, Greek tourism report
Photo Source: Wikimedia Commons Copyright: Michael W. Pendergrass License: CC-BY-SA
25/04 22:00
Greek FM talks with Kuwaiti counterpart on bilateral relations, regional cooperation
25/04 14:49
Prices of products in Easter Basket the same or lower in Greece than in 2023
25/04 13:57
25/04 12:44
Greece and China to ink cooperation protocols in the fisheries sector
25/04 09:53
Extended shop opening hours for Easter in Greece start on Thursday
25/04 02:19
Athens Airport voted as the best in marketing strategy at European awards in Denmark
25/04 02:10
President of Hellenic Republic visits La Chascona Museum in visit to Chile
24/04 21:31
Thirty-one Greek political parties to take part in European Parliament elections
24/04 21:25
Payment by bank cards now accepted on Athens Airport Express bus lines
24/04 14:12
Herculaneum papyri unveil more than location of Plato's tomb in Athens
23/04 23:52
Greece’s New Ambassador to the United States visits Queens in New York
23/04 21:49
Traffic regulations in Athens due to the Olympic Torch Relay on Thursday-Friday
23/04 20:59
President of Hellenic Republic wraps up visit to Uruguay at parliament
23/04 15:44
Greek government will pass legislation halving commission paid for POS transactions
23/04 15:03
Precise location of Plato's burial site unveiled by ancient papyrus
22/04 22:33
'Nature Positive' peport highlights new collaborative era in travel & tourism
22/04 21:25
22/04 20:37
Greek and Turkish delegations discuss Confidence Building Measures for 2024
22/04 18:29
Over 114,000 Greek Diaspora citizens register to vote by post in the European elections
22/04 13:40
19/04 01:29
Athens State Orchestra presents 'St. Matthew's Passion' by Bach on April 30th
18/04 21:49
Greek Climate Change Minister signs memorandum for Attica fire protection zones
18/04 20:32
'Easter Basket' and 'Godparents basket' to be put into effect next week in Greece
18/04 20:17
18/04 17:40
17/04 21:06
Thessaloniki Port: Performance growth for 2023 with record container throughput
17/04 20:57
Traffic regulations imposed in Athens for the 41st Peace Marathon on Sunday
17/04 20:52
17/04 18:15
Greek Foreign Minister addresses the 9th Our Ocean Conference in Athens
17/04 17:12
16/04 21:02
NHM hosts the Trial of Pericles at the Harris Theater in Chicago on April 17
16/04 20:17
Greece will invest $830 million to protect marine biodiversity
16/04 01:46
New York Greek Independence Parade honors 1821 and solemn Cyprus Anniversary
16/04 01:35
Olympic Games Paris 2024: Olympic Flame to be lit at Ancient Olympia in Greece
16/04 00:29
European Committee of Regions and UN release study on Rural Tourism
15/04 20:41
15/04 19:58
Minister: Greece is transforming into a hub for exporting quality agri-food products
15/04 18:51
Greek Environment Minister meets Chinese Deputy Minister of Natural Resources
13/04 00:13
UN Tourism and Croatia to launch Research Centre for Sustainable Tourism
12/04 00:03
2024 marks a critical year in the enduring strength of Greek-German relations
12/04 00:00
11/04 22:07
Ambassador: US committed to upgrade of Greek military and support NATO's SE flank
11/04 19:40
Hellenic Pride on display at rainy Chicago Greek Independence Day Parade
11/04 02:06
Delphi Economic Forum IX: Energy collaboration a 'key' in Greek-Bulgarian relations
11/04 01:58
UN Tourism launches investment guidelines for Albania sector
10/04 19:01
Greek FinMin: New package of economic measures in 2025 to lower taxes, raise pensions
10/04 18:25
Greek city of Nafplion hosts Mediterranean Yacht Show for ninth year running
09/04 23:57
Greek PM on Tilos: Innovative projects for a cyclical economy are of key significance
09/04 23:55
UN Tourism members promote agenda for Europe as region leads global recovery
09/04 23:46
HFS presents 1968, Rousing Docudrama about Greece’s First European Cup April 21
09/04 22:48
Stolen 7th-century BC oenochoe returned to Greece by Hanover museum, municipality
09/04 22:42
Greek civil servants confederation ADEDY to strike on May 21
09/04 21:55
Greek Migration Minister meets Senior US Coordinator for Lawful Migration
08/04 23:48
08/04 23:41
Elliniko-Argyroupoli Mayor marches in Greek Independence Philadelphia Parade
08/04 21:53
Project Voria casino complex in Maroussi moving ahead after environmental report
08/04 21:36
Minister: Up to 120 delegations to take part in 9th Our Ocean Conference in Athens
08/04 19:22
Direct flight from Shanghai to Athens offers access to key tourism market for Greece
08/04 18:31
AI conference to attract distinguished speakers to Thessaloniki on April 25-27
04/04 23:28
City of San Jose marks March 25 with 16th Annual Greek Flag Raising Event
04/04 22:16
Urban plans published for seven townships in Thessaloniki and Attica of Greece
04/04 17:24
FinMin: The new EU economic and fiscal framework is good for Greece
04/04 15:30
Greek PM meets with the chiefs of the international pharmaceutical manufacturers
04/04 00:15
Deputy Minister for Macedonia-Thrace meets US Embassy Deputy Mission Chief
03/04 20:12
Syracuse AHEPA Chapter 37 marks March 25th Greek Independence Day
03/04 18:10
Greece's Delphi Economic Forum on April 10-13 to focus on 'The Great Transition'
03/04 16:42
Minister: Industrial production has returned to the pre-crisis levels in Greece
02/04 18:06
30/03 23:21
Eleni Gatzoyiannis scholarship offered to Greek students at Boston University
29/03 16:44
3rd edition of 'This is Athens - City Festival' with 250+ events from May 1 until June 2
29/03 15:53
Athens Metro station Aghia Varvara to stay closed on Saturday and Sunday
29/03 13:55
Greek Foreign Minister for Economic Diplomacy concludes visit to Montenegro
29/03 12:00
29/03 11:51
28/03 18:41
Attica Region to channel 640 bln euros to services of vulnerable and disadvantaged groups
28/03 17:32
Greece to auction three-month T-bills on April 3, 2024 in a book entry form
28/03 15:46
Greece's Meteora Pyli Geopark added to UNESCO Global Geoparks network
28/03 14:44
IPTO announces framework agreement tender for undersea power cables in Greece
28/03 11:49
IOBE: Construction sector in Greece records robust growth and good prospects
26/03 23:51
St. Thomas Hellenic School honors 1821 and the Feast of the Annunciation in NJ
26/03 21:59
PM at Economic Club of Canada: Greece is an attractive investment destination
26/03 17:56
Greek State budget primary balance reaches a surplus of 3,378 million euros
26/03 11:45
Ancient Messene to get upgraded visitors' facilities after approval by Council
23/03 17:43
New requirements for 'Golden Visa' program to kick in on March 31
23/03 16:49
Athenians continue to head out of the Greek Capital for March 25 long weekend
23/03 16:47
Greek Parliament lights to be turned off for Earth Hour 8:30-9:30 pm
22/03 21:54
US President on Greek Independence Day: Alliance with Greece stronger than ever
22/03 19:51
High diplomacy and geopolitics at Delphi Economic Forum IX in Greece
22/03 19:32
Tax authorities enable payments with foreign bank cards in Greece
22/03 14:19
22/03 00:24
Greece ranks first on list of countries with fastest business environment progress
22/03 00:02
Hellenic Police acquires first electric VAN-type highway patrol vehicle
21/03 22:41
21/03 15:33
Unseen Museum presents "The stele of the twin babies" exhibition in Athens
20/03 22:48
Health Minister: 95% of Greek hospitals to perform afternoon surgeries
20/03 21:52
Greek Deputy Minister of Justice meets delegation from US Embassy in Athens
20/03 21:44
Greek Interior Minister to visit United States and Canada on postal vote
20/03 20:55
Philadelphia Icarians mark 85th Anniversary and organize Apokriatiko Dance
20/03 18:01
Development Minister: We continue the battle against high prices in Greece
19/03 22:28
President of the Hellenic Republic meets her Ethiopian counterpart in Athens
Herculaneum papyri unveil more than location of Plato's tomb in Athens
Greek FM talks with Kuwaiti counterpart on bilateral relations, regional cooperation
Extended shop opening hours for Easter in Greece start on Thursday
Prices of products in Easter Basket the same or lower in Greece than in 2023
President of Hellenic Republic visits La Chascona Museum in visit to Chile
Payment by bank cards now accepted on Athens Airport Express bus lines
Thirty-one Greek political parties to take part in European Parliament elections
Athens Airport voted as the best in marketing strategy at European awards in Denmark
Greece and China to ink cooperation protocols in the fisheries sector
Greek president organizes reception for diplomats at Presidential Mansion
Greek PM inaugurates 'One & Only Aesthesis' tourist resort in suburb of Glyfada
Temporary residence for displaced Ukrainians extended in Greece to March 2025
The bratti hotel signage at the XENIA 2023 exhibition & the Architect Show 2023 event
Mandarin Oriental, Costa Navarino and The Dolli among the world's best new luxury hotels in 2023
TUI chief forecast: Tourism sector in Greece to break all records during 2024
Impressive statue of Hercules unearthed in Philippi of Northern Greece
IPTO chief: Starting construction on Greece-Cyprus-Israel power interconnector
Metro station 'Maniatika' near Piraeus Port to be closed on Saturday and Sunday
Greece’s New Ambassador to the United States visits Queens in New York
Deadline to file taxes is extended in Greece to July 31 by Finance Ministry
New publication: 'I am not Maria - I am Callas: Her real life and an eon of myths'
CEO: The goal is for PPC to become a leading player in Southeast Europe
Consumers to see price cuts up to 18.1% in 3,000 Greek supermarket products as of Friday
Greek city of Nafplion hosts Mediterranean Yacht Show for ninth year running